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Furanylfentanyl (Fu-F) is an opioid analgesic that is an analog of fentanyl and has been sold as a designer drug. It has an ED50 value of 0.02 mg/kg in mice. This makes it approximately one fifth as potent as fentanyl.

Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.

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Life-threatening adverse reactions caused by this drug use have been observed in Sweden and Canada. At least seven deaths in Cook County, Illinois, have been linked to this drug in 2016, with additional deaths in suburban Chicago in 2017.

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Detection in biological fluids
Furanylfentanyl may be measured in blood or urine to monitor for abuse, confirm a diagnosis of poisoning, or assist in a medicolegal death investigation. Commercially available immunoassays are often used as initial screening tests, but chromatographic techniques are generally used for confirmation and quantitation. Blood furanylfentanyl concentrations are expected to be in a range of 1-45 μg/L in victims of fatal overdosa

The United States Drug Enforcement Administration (DEA) proposed a temporary placement of this drug into Schedule I of the Controlled Substances Act on 27 September 2016. On November 29, 2016, the DEA issued its final rule, making Schedule I.

Chinese manufacture
According to the DEA, fentanyl and its analog are being mass-produced in clandestine labs in China and are then smuggled into the United States. These new variants of fentanyl are manufactured by Chinese chemists in order to circumvent restrictions on the sale of fentanyl in the United States.

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